Ukraine progressed to this stage after a hugely impressive 3-1 victory over Scotland in an emotionally-charged encounter.
The winners of this fixture in Cardiff will be placed into Group B for the World Cup alongside England, Iran and USA.
Here’s all the information that you need to know ahead of the game.
MORE: Scotland vs. Ukraine result: Yarmolenko keeps his country’s 2022 World Cup dreams alive
How to watch Wales vs. Ukraine
The match takes place on Sunday, June 5 at the Cardiff City Stadium with kickoff at 5pm local time.
UK: The match will be shown on Sky Sports and Sky streaming platforms.
USA: ESPN will televise the game live and that channel is streamed on fuboTV and on ESPN+ for subscribers to the ESPN streaming platform. It will be carried in Spanish by Univision streaming platform ViX.
Canada: The game will be shown live on TLN and on UEFA.tv.
Australia: Optus Sport show the UEFA World Cup qualifiers in Australia.
Wales vs. Ukraine lineups
Wales gave a chance to some of the fringe members of the squad against Poland in their most recent Nations League outing, but the likes of Gareth Bale and Aaron Ramsey are starting this crucial fixture.
Wales starting lineup (3-4-3, left to right): 1-Hennessey (GK) — 4-B. Davies, 6-Rodon, 15-Ampadu — 3-N. Williams, 7-Allen, 10-Ramsey, 13-Roberts — 20-James, 13-Moore, 11-Bale.
Wales subs (12): 12-Ward (GK), 21-A. Davies (GK), 2-Gunter, 5-Mepham, 8-Wilson, 9-Johnson, 16-Morrell, 17-Norrington-Davies, 18-J. Williams, 19-Harris, 22-Thomas, 23-Matondo
Ukraine name an identical side to the one that got the better of Scotland. Andriy Yarmolenko captains the side from his wide position, wearing the No. 7 jersey.
Ukraine lineup (4-1-4-1, left to right): Bushchan (GK) — 16-Mykolenko, 22-Matviyenko, 13-Zabarnyi, 21-Karavaev — 6-Stepanenko — 15-Tsygankov, 17-Zinchenko, 8-Malinovskyi, 7-Yarmolenko — 9-Yaremchuk.
Ukraine subs (12): 12-Pyatov (GK), 23-Riznyk (GK), 2-Sobol, 3-Bondar, 19-Kacharaba, 4-Syrota, 5-Sydorchuk, 10-Shaparenko, 18-Pikhalyonok, 20-Zubkov, 11-Dovbyk, 14-Mudryk
Wales vs. Ukraine betting odds
Ukraine will be confident after their victory against Scotland, but Wales are considered the favourites to win.
